The Constitution won't support that, but does allow their taxation since trannies are people and people affect interstate commerce, just as guns apparently do. Maybe the US can tax transgender people like it does to "gangster" weapons. The NFA of 1934 imposes a $200 making and transfer tax on most "gangster" weapons. To legally possess a; destructive device, machine gun, short barreled rifle, short barreled shotgun or a silencer, one must pay a $200 making or transfer tax, submit finger prints, get a CLEO sign off and register it with the AFT. An AOW ( any other weapon ) has the same requirements, but only a $5 transfer tax. An approved form 5 is required to transport an NFA weapon over state lines.
Since 1934 there's only been like 2 criminal uses of a legally owned NFA weapon and one was a dirty cop in Ohio who used one to murder and rip off a drug dealer.
I bet if trannies were registered and taxed, they wouldn't cause any trouble.